Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.38 |
| ▸ | HNF4A | P41235 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596009 | 0.83 | ALOX5 (0.50) | ALOX5HPGDKDM4EMEN1USP2 | |
| SCHEMBL4596274 | 0.73 | ALOX5 (0.50) | ALOX5HPGDKDM4EMEN1USP2 | |
| SCHEMBL17878569 | 0.72 | ALOX5 (0.57) | ALOX5HPGDKDM4EMEN1USP2 | |
| SCHEMBL51054 | 0.72 | ALOX5 (0.57) | ALOX5HPGDKDM4EMEN1USP2 | |
| SCHEMBL1038159 | 0.71 | ALOX5 (0.43) | ALOX5HPGDKDM4EMEN1USP2 | |
| SCHEMBL6881260 | 0.70 | MGLL (0.42) | ALOX5HPGDKDM4EMEN1USP2 | |
| SCHEMBL4948052 | 0.70 | ACMSD (0.47) | ALOX5HPGDKDM4ELMNAMAPT | |
| SCHEMBL22888664 | 0.70 | ALOX5 (0.46) | ALOX5HPGDKDM4EMEN1USP2 | |
| SCHEMBL28416425 | 0.68 | DPP4 (0.54) | LMNA | |
| SCHEMBL51614 | 0.67 | ALOX5 (0.55) | ALOX5HPGDKDM4EMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163953-B2 | Compounds for lysosomal modulation and methods of use | UNIVERSITY OF CONNECTICUT (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090281178-A1 | Compounds for Lysosomal Modulation and Methods of Use | UNIVERSITY OF CONNECTICUT | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281178-A1 | Compounds for Lysosomal Modulation and Methods of Use | GAA, GBA1, CTSA | ALOX5 3047/4885HPGD 2575/4885KDM4E 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.