Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18417277 | 0.76 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL10075481 | 0.75 | BRD4 (0.46) | CYP3A4MAPTBRD4CREBBPGAA | |
| SCHEMBL8312132 | 0.71 | GAA (0.38) | RIPK1MAPTHTTSMN1; SMN2BRD4 | |
| SCHEMBL11923831 | 0.70 | CYP11B2 (0.41) | PDE3BPDE3ACYP3A4SIGMAR1CYP11B1 | |
| SCHEMBL24499294 | 0.69 | SIGMAR1 (0.38) | PDE3BPDE3ACHRNB2CHRNA4SIGMAR1 | |
| SCHEMBL16846521 | 0.68 | BRD4 (0.59) | PDE3BPDE3ABRD4CREBBPCYP11B1 | |
| SCHEMBL21212262 | 0.67 | CYP11B2 (0.41) | PDE3BPDE3ACYP3A4SIGMAR1CYP11B2 | |
| SCHEMBL18421618 | 0.67 | CHRNB2 (0.36) | PDE3BPDE3ACHRNB2CHRNA4SIGMAR1 | |
| SCHEMBL9853254 | 0.67 | GAA (0.39) | CYP3A4LMNAMAPTSMN1; SMN2BRD4 | |
| SCHEMBL22513210 | 0.67 | RIPK1 (0.52) | RIPK1CYP3A4SIGMAR1AHRCHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273241-B2 | Cortistatin analogues and syntheses and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273241-B2 | Cortistatin analogues and syntheses and uses thereof | CDK19, CDK9, CDK1 | RIPK1 2011/4885PDE3B 1037/4885PDE3A 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.