Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24242591 | 1.00 | PPARA (0.42) | PPARAPPARGMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL24239865 | 0.86 | PPARG (0.38) | PPARAPPARGMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL12518234 | 0.84 | ACHE (0.45) | MAPTSMN1; SMN2L3MBTL1ATMCYP3A4 | |
| SCHEMBL11382828 | 0.83 | MAPT (0.50) | PPARAPPARGMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8721308 | 0.83 | PPARG (0.36) | PPARAPPARGL3MBTL1 | |
| SCHEMBL5972998 | 0.83 | MAPT (0.53) | MAPTSMN1; SMN2L3MBTL1ATMMEN1 | |
| SCHEMBL13849363 | 0.78 | PPARG (0.36) | PPARAPPARG | |
| SCHEMBL18632252 | 0.75 | MAPT (0.43) | PPARAPPARGMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL8418226 | 0.75 | MEN1 (0.58) | PPARAPPARGMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL16479155 | 0.75 | CA5A (0.48) | PPARAPPARGMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10272079-B2 | NHE3-binding compounds and methods for inhibiting phosphate transport | ARDELYX, INC. (US) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10272079-B2 | NHE3-binding compounds and methods for inhibiting phosphate transport | SLC34A3, SLC34A2, SLC34A1 | PPARA 4068/4885PPARG 4160/4885MAPT 4323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.