Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051337 | 0.83 | SMN1; SMN2 (0.70) | MAPTSMN1; SMN2L3MBTL1ATMHSD17B3 | |
| SCHEMBL10031827 | 0.83 | PGR (0.47) | SMN1; SMN2L3MBTL1ALDH1A1PGRAR | |
| SCHEMBL20953597 | 0.83 | PPARA (0.42) | MAPTSMN1; SMN2L3MBTL1ATMKMT2A | |
| SCHEMBL24242591 | 0.83 | PPARA (0.42) | MAPTSMN1; SMN2L3MBTL1ATMKMT2A | |
| SCHEMBL10432594 | 0.81 | NPC1 (0.39) | MAPTSMN1; SMN2L3MBTL1HSD17B3RAB9A | |
| SCHEMBL11828224 | 0.81 | GSK3B (0.61) | MAPTHSD17B3RAB9ANPC1ALDH1A1 | |
| SCHEMBL12518234 | 0.80 | ACHE (0.45) | MAPTSMN1; SMN2L3MBTL1ATMALDH1A1 | |
| SCHEMBL26054306 | 0.80 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2L3MBTL1ALDH1A1HPGD | |
| Ethyne SCHEMBL8050785 | 0.79 | SMN1; SMN2 (0.64) | MAPTSMN1; SMN2L3MBTL1ATMHSD17B3 | |
| SCHEMBL965418 | 0.78 | RAB9A (0.63) | MAPTSMN1; SMN2L3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216820-A1 | POLYARYLETHER KETONE IMIDE SULFONE ADHESIVES | The Boeing Company (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-1212335-B1 | GLUCOPYRANOSIDES CONJUGATES OF 2-(4-HYDROXY-PHENYL)-1- 4-(2-AMIN-1-YL-ETHOXY)-BENZYL]-1H-INDOL-5-OLS | WYETH CORP (US) | 2006-01-18 | — | — | EP | disclosed |
| US-6537971-B2 | Useful as tissue selective estrogenic agents, for therapy and prophylaxis of cardiovascular disorders, for increasing cognition or treating or inhibiting dementias or Alzheimer's Disease | WYETH | 2003-03-25 | — | — | US | disclosed |
| US-20020142971-A1 | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols | AMERICAN HOME PRODUCTS CORPORATION | 2002-10-03 | — | — | US | disclosed |
| EP-1212335-A1 | GLUCOPYRANOSIDES CONJUGATES OF 2-(4-HYDROXY-PHENYL)-1- 4-(2-AMIN-1-YL-ETHOXY)-BENZYL]-1H-INDOL-5-OLS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-06-12 | — | — | EP | disclosed |
| US-6380166-B1 | USEFUL AS TISSUE ELECTIVE ESTROGENIC AGENTS, USED IN HORMONE REPLACEMENT THERAPY FOR BONE LOSS PREVENTION IN POST-MENOPAUSAL WOMEN | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-30 | — | — | US | disclosed |
| WO-2001019839-A1 | GLUCOPYRANOSIDES CONJUGATES OF 2-(4-HYDROXY-PHENYL)-1-[4-(2-AMIN-1-YL-ETHOXY)-BENZYL]-1H-INDOL-5-OLS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020142971-A1 | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols | SHBG, GPER1, SULT1E1 | MAPT 4045/4885SMN1; SMN2 4138/4885L3MBTL1 2539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.