Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bisoprolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 4/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.83 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | THRB | P10828 | 1/20 | 0.83 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.83 |
| ▸ | APEX1 | P27695 | 1/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.83 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.62 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.62 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bisoprolol SCHEMBL20961 | 1.00 | ADRB1 (1.00) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL233810 | 1.00 | ADRB1 (1.00) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL6510329 | 1.00 | ADRB1 (1.00) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL16821829 | 0.99 | ADRB1 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL16821831 | 0.99 | ADRB1 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL4269272 | 0.99 | ADRB1 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL3137111 | 0.99 | ADRB2 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL3137123 | 0.99 | ADRB2 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL14343724 | 0.94 | ADRB2 (0.89) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL28880254 | 0.94 | ADRB2 (0.89) | ADRB1ADRB2ADRB3LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 22415 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| WO-2026103722-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF COAGULATION FACTOR XI (FXI) | SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD. (CN) | 2026-05-21 | — | — | WO | claimed |
| WO-2026103833-A1 | PHARMACEUTICAL COMPOSITION OF ARNI AND BISOPROLOL OR SALT THEREOF, AND USE THEREOF | 深圳信立泰药业股份有限公司 | 2026-05-21 | — | — | WO | claimed |
| CN-224227077-U | Immobilized enzyme reactor for bisoprolol synthesis | 浙江希尔化工股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4731194-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT | CSP Technologies, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| EP-4727545-A2 | COMBINATION TREATMENTS FOR DEPRESSION AND OTHER DISORDERS | Neurawell Therapeutics (US) | 2026-04-22 | — | — | EP | claimed |
| EP-4722714-A1 | SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) | Korea Institute of Science and Technology (KR) | 2026-04-08 | — | — | EP | claimed |
| US-20260076953-A1 | METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2026-03-19 | — | — | US | claimed |
| EP-4709379-A1 | NMDAR ANTAGONIST FOR THE TREATMENT OF INFLAMMATORY DISEASES IN PATIENTS WITH DEPRESSION COMORBIDITY | THE SARAH HERZOG MEMORIAL HOSPITAL-EZRATH NASHIM (IL) | 2026-03-18 | — | — | EP | claimed |
| EP-4694856-A1 | CALENDAR MEDICATION BLISTER PACK, METHOD OF USING THEREOF AND ELECTRONIC SYSTEM OF MANAGEMENT OF INTERACTION WITH CALENDAR MEDICATION BLISTER PACK | Mili Healthcare Trade Fzco (AE) | 2026-02-18 | — | — | EP | claimed |
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0068160-B1 | USE OF 1-(P-ISOPROPOXYETHOXYMETHYL-PHENOXY)-3-ISOPROPYLAMINOPROPAN-2-OL FOR THE PREPARATION OF A MEDICAMENT FOR THE REDUCTION OF INTERNAL PRESSURE IN THE EYE | MERCK PATENT GmbH (DE) | 1986-10-29 | — | — | EP | claimed |
| EP-0163237-A2 | Di- and tri-peptidal renin inhibitors | MERCK & CO. INC. (US) | 1985-12-04 | — | — | EP | claimed |
| EP-0157409-A2 | Renin inhibitors containing 2-substituted statine | MERCK & CO. INC. (US) | 1985-10-09 | — | — | EP | claimed |
| EP-0156318-A2 | C-terminal amide cyclic renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0156322-A2 | Renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| US-4522829-A | 1-(p-2-Isopropoxyethoxymethyl-phenoxy)-3-isopropylamino-propan-2-ol for decreasing the intra-ocular pressure and an ophthalmic preparation thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-06-11 | — | — | US | claimed |
| EP-0129189-A2 | Renin inhibitors containing a C-terminal amide cycle and compositions and combinations containing the same | MERCK & CO. INC. (US) | 1984-12-27 | — | — | EP | claimed |
| EP-0068160-A1 | Use of 1-(p-Isopropoxyethoxymethyl-phenoxy)-3-isopropylaminopropan-2-ol for the preparation of a medicament for the reduction of internal pressure in the eye | MERCK PATENT GmbH (DE) | 1983-01-05 | — | — | EP | claimed |
| US-4258062-A | ISOPRENALINE ANTAGONISTS EFFECTING HEART RATE AND BLOOD PRESSURE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-03-24 | — | — | US | claimed |