Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bisoprolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 4/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.83 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | THRB | P10828 | 1/20 | 0.83 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.83 |
| ▸ | APEX1 | P27695 | 1/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.83 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.62 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.62 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bisoprolol SCHEMBL20961 | 1.00 | ADRB1 (1.00) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL233810 | 1.00 | ADRB1 (1.00) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL20960 | 1.00 | ADRB1 (1.00) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL16821829 | 0.99 | ADRB1 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL16821831 | 0.99 | ADRB1 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL4269272 | 0.99 | ADRB1 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL3137111 | 0.99 | ADRB2 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL3137123 | 0.99 | ADRB2 (0.98) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL14343724 | 0.94 | ADRB2 (0.89) | ADRB1ADRB2ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL28880254 | 0.94 | ADRB2 (0.89) | ADRB1ADRB2ADRB3LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005099699-A1 | COMBINATION OF (S)-AMLODIPINE AND A BETA-BLOCKER, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-10-27 | — | — | WO | disclosed |