Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bisoprolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 4/20 | 0.98 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.98 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 4/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | THRB | P10828 | 1/20 | 0.82 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.82 |
| ▸ | APEX1 | P27695 | 1/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bisoprolol SCHEMBL3137123 | 1.00 | ADRB2 (0.98) | ADRB2ADRB1ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL20961 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL20960 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL6510329 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL233810 | 0.99 | ADRB1 (1.00) | ADRB2ADRB1ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL16821831 | 0.98 | ADRB1 (0.98) | ADRB2ADRB1ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL16821829 | 0.98 | ADRB1 (0.98) | ADRB2ADRB1ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL4269272 | 0.98 | ADRB1 (0.98) | ADRB2ADRB1ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL14343724 | 0.93 | ADRB2 (0.89) | ADRB2ADRB1ADRB3LMNANFKB1 | |
| Bisoprolol SCHEMBL28880254 | 0.93 | ADRB2 (0.89) | ADRB2ADRB1ADRB3LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357945-B1 | ADHESIVE POLYMER AND MEDICAL ADHESIVE PATCH | TEIKOKU SEIYAKU KK (JP) | 2024-10-30 | — | — | EP | claimed |
| CN-108290990-B | Adhesive polymer and medical adhesive patch | 帝国制药株式会社 | 2022-02-01 | — | — | CN | claimed |
| US-11077069-B2 | Adhesive polymer and medical adhesive patch | TEIKOKU SEIYAKU CO., LTD (JP) | 2021-08-03 | — | — | US | claimed |
| US-20180280315-A1 | ADHESIVE POLYMER AND MEDICAL ADHESIVE PATCH | TEIKOKU SEIYAKU CO., LTD. (JP) | 2018-10-04 | — | — | US | claimed |
| EP-3357945-A1 | ADHESIVE POLYMER AND MEDICAL ADHESIVE PATCH | Teikoku Seiyaku Co., Ltd. (JP) | 2018-08-08 | — | — | EP | claimed |
| CN-119837946-A | Preparation method of spleen-strengthening and kidney-tonifying, heart-calming and nerve-soothing composition for activating blood circulation to dissipate blood stasis | 刘宏伟 | 2025-04-18 | — | — | CN | disclosed |
| EP-3357945-B1 | ADHESIVE POLYMER AND MEDICAL ADHESIVE PATCH | TEIKOKU SEIYAKU KK (JP) | 2024-10-30 | — | — | EP | disclosed |
| CN-112004520-B | Modified release pharmaceutical powder compositions comprising a gastric raft formation system with triggered pulsatile drug release | 特瑞斯制药公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-108290990-B | Adhesive polymer and medical adhesive patch | 帝国制药株式会社 | 2022-02-01 | — | — | CN | disclosed |
| US-11077069-B2 | Adhesive polymer and medical adhesive patch | TEIKOKU SEIYAKU CO., LTD (JP) | 2021-08-03 | — | — | US | disclosed |
| US-20180280315-A1 | ADHESIVE POLYMER AND MEDICAL ADHESIVE PATCH | TEIKOKU SEIYAKU CO., LTD. (JP) | 2018-10-04 | — | — | US | disclosed |
| EP-3357945-A1 | ADHESIVE POLYMER AND MEDICAL ADHESIVE PATCH | Teikoku Seiyaku Co., Ltd. (JP) | 2018-08-08 | — | — | EP | disclosed |
| CN-108290990-A | Binding property polymer and medical adhesive adhesive preparation | 帝国制药株式会社 | 2018-07-17 | — | — | CN | disclosed |
| US-20130006203-A1 | ADHESIVE PATCH CONTAINING BISOPROLOL | TOA EIYO LTD. (JP) | 2013-01-03 | — | — | US | disclosed |
| EP-2540289-A1 | ADHESIVE PATCH CONTAINING BISOPROLOL | Nitto Denko Corporation (JP) | 2013-01-02 | — | — | EP | disclosed |
| EP-2203192-A1 | WOUND CARE FORMULATION | Northern Health And Social Care Trust (GB) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009037500-A1 | WOUND CARE FORMULATION | NORTHERN HEALTH AND SOCIAL CARE TRUST (GB) | 2009-03-26 | — | — | WO | disclosed |