Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.51 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.51 |
| ▸ | ADH5 | P11766 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL19462652 | 0.96 | LMNA (0.62) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL2532397 | 0.87 | LMNA (0.78) | LMNAMAPTENPP2MKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL28701756 | 0.84 | LMNA (0.75) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL3250899 | 0.82 | CYP3A4 (0.71) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL2533488 | 0.80 | TSHR (0.84) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL171705 | 0.77 | LMNA (0.64) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL17672944 | 0.77 | LMNA (0.64) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL8108194 | 0.77 | LMNA (0.64) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL2234254 | 0.77 | LMNA (0.64) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL4295697 | 0.77 | LMNA (0.64) | LMNAMAPTENPP2MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163439-B2 | Electrolyte membranes and methods of use | THE UNIVERSITY OF AKRON (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090297915-A1 | ELECTROLYTE MEMBRANES AND METHODS OF USE | THE UNIVERSITY OF AKRON (US) | 2009-12-03 | — | — | US | disclosed |