SCHEMBL20969714

SCHEMBL20969714

CCC(c1ccc(C(=O)O)cc1)N(CCc1cc(C)c(OC)cc1C)c1nc2cccc(F)c2s1

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.35
MEN1 O00255 3/20 0.35
RAD52 P43351 4/20 0.34
TRPM8 Q7Z2W7 1/20 0.33
KDM4E B2RXH2 3/20 0.33
KARS1 Q15046 1/20 0.33
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
SGPL1 O95470 5/20 0.32
LMNA P02545 2/20 0.32
IGF1R P08069 1/20 0.31
MAPK8 P45983 1/20 0.31
AGTR1 P30556 1/20 0.31
AGTR2 P50052 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20969711 0.93 KMT2A (0.33) KMT2AMEN1RAD52TRPM8KDM4E
SCHEMBL20969684 0.91 TRPM8 (0.34) KMT2AMEN1RAD52TRPM8KDM4E
SCHEMBL20969662 0.89 KARS1 (0.37) KMT2AMEN1TRPM8KDM4EKARS1
SCHEMBL20969581 0.89 TAS2R14 (0.38) KMT2AMEN1RAD52TRPM8KDM4E
SCHEMBL20969638 0.89 KMT2A (0.34) KMT2AMEN1RAD52TRPM8KDM4E
SCHEMBL20969670 0.88 KARS1 (0.33) KMT2AMEN1RAD52TRPM8KDM4E
SCHEMBL20969607 0.88 KARS1 (0.33) KMT2AMEN1RAD52TRPM8KDM4E
SCHEMBL20969702 0.84 KARS1 (0.37) KMT2AMEN1TRPM8KDM4EKARS1
SCHEMBL20969708 0.84 TRPM8 (0.33) KMT2AMEN1RAD52TRPM8KDM4E
SCHEMBL20969620 0.83 KARS1 (0.49) KMT2AMEN1TRPM8KARS1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3483149-B1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME YUHAN CORP (KR) 2021-01-13 EP claimed
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same YUHAN CORPORATION (KR) 2019-08-20 US claimed
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same YUHAN CORPORATION (KR) 2019-05-16 US claimed
EP-3483149-A1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Yuhan Corporation (KR) 2019-05-15 EP claimed
EP-3483149-B1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME YUHAN CORP (KR) 2021-01-13 EP disclosed
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same YUHAN CORPORATION (KR) 2019-08-20 US disclosed
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same YUHAN CORPORATION (KR) 2019-05-16 US disclosed
EP-3483149-A1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Yuhan Corporation (KR) 2019-05-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same ILK, SBDS, BDKRB1 KMT2A 2573/4885MEN1 2715/4885RAD52 4542/4885
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same ILK, SBDS, BDKRB1 KMT2A 2573/4885MEN1 2715/4885RAD52 4542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.