SCHEMBL20969730

SCHEMBL20969730

CCNc1ccc(OC)c(Br)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
MAPT P10636 5/20 0.51
KMT2A Q03164 5/20 0.49
MEN1 O00255 4/20 0.49
ALDH1A1 P00352 6/20 0.44
PGK1 P00558 2/20 0.42
HTR2A P28223 1/20 0.42
KDM4E B2RXH2 2/20 0.42
GAA P10253 2/20 0.42
CASP1 P29466 2/20 0.42
HSD17B10 Q99714 2/20 0.42
RECQL P46063 2/20 0.42
USP2 O75604 1/20 0.42
THRB P10828 1/20 0.42
ALOX15 P16050 1/20 0.42
HTT P42858 1/20 0.42
BLM P54132 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
LMNA P02545 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27261405 0.85 ALDH1A1 (0.51) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1
SCHEMBL423387 0.82 MAPT (0.56) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1
SCHEMBL30480119 0.82 MAPT (0.56) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1
Hydrochloric Acid SCHEMBL7102293 0.81 MAPT (0.54) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1
Bromide SCHEMBL11715283 0.81 MAPT (0.54) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1
Hydrochloric Acid SCHEMBL5123360 0.81 MAPT (0.54) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1
SCHEMBL20715031 0.81 L3MBTL1 (0.50) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1
SCHEMBL12444463 0.81 L3MBTL1 (0.50) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1
SCHEMBL12895546 0.80 EPHX2 (0.43) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1
SCHEMBL8156015 0.80 L3MBTL1 (0.49) L3MBTL1SMN1; SMN2MAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3483149-B1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME YUHAN CORP (KR) 2021-01-13 EP disclosed
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same YUHAN CORPORATION (KR) 2019-08-20 US disclosed
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same YUHAN CORPORATION (KR) 2019-05-16 US disclosed
EP-3483149-A1 BENZO[D]THIAZOLE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME Yuhan Corporation (KR) 2019-05-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190142809-A1 Benzo[D]Thiazole Derivative Or Salt Thereof, And Pharmaceutical Composition Including Same ILK, SBDS, BDKRB1 L3MBTL1 1733/4885SMN1; SMN2 2540/4885MAPT 2062/4885
US-10383859-B2 Benzo[d]thiazole derivative or salt thereof, and pharmaceutical composition including same ILK, SBDS, BDKRB1 L3MBTL1 1733/4885SMN1; SMN2 2540/4885MAPT 2062/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.