SCHEMBL20984331

SCHEMBL20984331

COc1cc(Cl)cc(NNP(=O)(O)O)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX1 P51575 1/20 0.40
CLK1 P49759 1/20 0.40
CLK2 P49760 1/20 0.40
DYRK1A Q13627 1/20 0.40
CLK4 Q9HAZ1 1/20 0.40
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
LMNA P02545 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HTR1A P08908 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
CNR1 P21554 1/20 0.37
DRD1 P21728 1/20 0.37
HTR2A P28223 1/20 0.37
ADORA2A P29274 1/20 0.37
OPRM1 P35372 1/20 0.37
SCN5A Q14524 1/20 0.37
SCN9A Q15858 1/20 0.37
SCN2A Q99250 1/20 0.37
SCN3A Q9NY46 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20984548 0.88 GAA (0.46) P2RX1NPC1RAB9AKMT2ASMN1; SMN2
SCHEMBL20984699 0.81 CLK1 (0.40) CLK1CLK2DYRK1ACLK4NPC1
Phosphoric Acid SCHEMBL28200708 0.79 P2RX1 (0.41) P2RX1CLK1CLK2DYRK1ACLK4
SCHEMBL20984167 0.77 CLK1 (0.48) P2RX1CLK1CLK2DYRK1ACLK4
SCHEMBL20984901 0.76 MEN1 (0.52) CLK1NPC1RAB9ALMNANPSR1
SCHEMBL20984215 0.75 L3MBTL1 (0.56) CLK1NPC1RAB9ALMNANPSR1
SCHEMBL20984418 0.74 PTGS2 (0.51) NPC1RAB9ANPSR1KMT2ASMN1; SMN2
SCHEMBL29555889 0.71 MAPT (0.56) P2RX1NPC1RAB9ANPSR1CNR1
SCHEMBL30038868 0.71 KMT2A (0.50) P2RX1NPC1RAB9ALMNAHTR1A
SCHEMBL8312905 0.71 ALDH1A1 (0.42) P2RX1NPC1RAB9ALMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11040938-B2 Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts SHANGHAI HYBRID-CHEM TECHNOLOGIES (CN) 2021-06-22 US claimed
CN-107663161-B Continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt 上海惠和化德生物科技有限公司 2020-04-10 CN claimed
US-20190152896-A1 Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts SHANGHAI HYBRID-CHEM TECHNOLOGIES (CN) 2019-05-23 US claimed
US-11040938-B2 Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts SHANGHAI HYBRID-CHEM TECHNOLOGIES (CN) 2021-06-22 US disclosed
CN-107663161-B Continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt 上海惠和化德生物科技有限公司 2020-04-10 CN disclosed
US-20190152896-A1 Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts SHANGHAI HYBRID-CHEM TECHNOLOGIES (CN) 2019-05-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11040938-B2 Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts HPD, TYR, PDK2 P2RX1 1513/4885CLK1 585/4885CLK2 434/4885
US-20190152896-A1 Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts HPD, TYR, PDK2 P2RX1 1513/4885CLK1 585/4885CLK2 434/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.