Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20988926 | 0.81 | ALDH1A1 (0.57) | TRPV1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL9425805 | 0.79 | TRPV1 (0.81) | TRPV1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL20988923 | 0.78 | C3AR1 (0.46) | ALDH1A1MEN1KMT2APOLBKDM4E | |
| SCHEMBL20989035 | 0.78 | FKBP1A (0.59) | LMNASMN1; SMN2HTTALDH1A1MEN1 | |
| SCHEMBL2830225 | 0.78 | TRPV1 (0.64) | TRPV1LMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9425973 | 0.78 | TRPV1 (0.83) | TRPV1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL20988916 | 0.77 | KMT2A (0.48) | LMNAALDH1A1KMT2APOLBTSHR | |
| SCHEMBL20989033 | 0.77 | SIGMAR1 (0.50) | LMNASMN1; SMN2HTTALDH1A1KMT2A | |
| SCHEMBL15985215 | 0.76 | TRPV1 (0.61) | TRPV1LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL14218026 | 0.76 | TRPV1 (0.61) | TRPV1LMNASMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOG (US) | 2019-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | KRAS, NRAS, HRAS | TRPV1 3933/4885LMNA 3462/4885SMN1; SMN2 4615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.