Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 11/20 | 0.58 |
| ▸ | MMP2 | P08253 | 6/20 | 0.51 |
| ▸ | MMP13 | P45452 | 6/20 | 0.51 |
| ▸ | MMP9 | P14780 | 4/20 | 0.51 |
| ▸ | MMP8 | P22894 | 4/20 | 0.51 |
| ▸ | MMP1 | P03956 | 4/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | MMP14 | P50281 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP16 | P51512 | 1/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12213876 | 0.84 | CASP1 (0.47) | CASP1MMP2MMP13MMP9MMP8 | |
| SCHEMBL7953769 | 0.82 | CASP1 (0.55) | CASP1 | |
| SCHEMBL12190245 | 0.82 | MMP1 (0.54) | CASP1MMP2MMP13MMP9MMP8 | |
| SCHEMBL10849395 | 0.80 | CASP1 (0.57) | CASP1MMP2MMP13MMP9MMP8 | |
| SCHEMBL32661421 | 0.79 | CASP1 (0.51) | CASP1MMP2MMP13MMP9MMP8 | |
| SCHEMBL158361 | 0.79 | CASP1 (0.51) | CASP1MMP2MMP13MMP9MMP8 | |
| SCHEMBL146565 | 0.79 | CASP1 (0.50) | CASP1MMP2MMP13MMP9MMP8 | |
| SCHEMBL502864 | 0.79 | CASP1 (0.50) | CASP1MMP2MMP13MMP9MMP8 | |
| SCHEMBL1745319 | 0.78 | CASP1 (0.51) | CASP1MMP2MMP13 | |
| Ammonia Solution, Strong SCHEMBL1120715 | 0.78 | CASP1 (0.50) | CASP1MMP2MMP13MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190144380-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY | 2019-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144380-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS | TNNI3, TNNC1, TNNT2 | CASP1 1917/4885MMP2 4284/4885MMP13 4273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.