Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21019535 | 0.77 | AKR1B1 (0.35) | TOP2AVCP | |
| SCHEMBL21019948 | 0.77 | SIGMAR1 (0.31) | — | |
| SCHEMBL19806108 | 0.76 | VCP (0.36) | TOP2AVCP | |
| SCHEMBL19805944 | 0.76 | VCP (0.35) | VCP | |
| SCHEMBL21019518 | 0.75 | MGAM (0.35) | VCP | |
| SCHEMBL21019941 | 0.70 | VCP (0.35) | VCP | |
| SCHEMBL22912287 | 0.69 | KDM4E (0.32) | VCP | |
| SCHEMBL21019942 | 0.69 | VCP (0.33) | VCP | |
| SCHEMBL23897443 | 0.68 | EGFR (0.38) | VCP | |
| SCHEMBL22912304 | 0.68 | HSD17B10 (0.35) | VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11034680-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-06-15 | — | — | US | disclosed |
| US-20190152960-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152960-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | TOP2A 847/4885VCP 1667/4885 |
| US-11034680-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | TOP2A 847/4885VCP 1667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.