Griffonin

Griffonin

SCHEMBL21034847

N#C/C=C1/C=C[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.43
PTPN1 P18031 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.41
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
TYR P14679 1/20 0.38
POLB P06746 1/20 0.38
ACHE P22303 1/20 0.36
PTGS1 P23219 1/20 0.35
AMY2A P04746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Griffonin SCHEMBL28797041 1.00 MAPT (0.43) MAPTPTPN1L3MBTL1MEN1KMT2A
Griffonin SCHEMBL20995242 1.00 MAPT (0.43) MAPTPTPN1L3MBTL1MEN1KMT2A
Griffonin SCHEMBL21034801 1.00 MAPT (0.43) MAPTPTPN1L3MBTL1MEN1KMT2A
SCHEMBL21035198 0.92 PTPN1 (0.35) MAPTPTPN1L3MBTL1MEN1KMT2A
SCHEMBL29586077 0.89 PTPN1 (0.40) MAPTPTPN1L3MBTL1MEN1KMT2A
SCHEMBL21035195 0.80 PTPN1 (0.45) PTPN1L3MBTL1MEN1KMT2ATYR
SCHEMBL30615017 0.79 PTPN1 (0.44) MAPTPTPN1L3MBTL1MEN1KMT2A
SCHEMBL30089929 0.79 PTPN1 (0.44) MAPTPTPN1L3MBTL1MEN1KMT2A
SCHEMBL21034846 0.79 L3MBTL1 (0.42) MAPTPTPN1L3MBTL1MEN1KMT2A
Trehalose SCHEMBL166078 0.69 MAPT (0.56) MAPTPTPN1L3MBTL1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026090605-A2 COMPOSITIONS AND METHODS COMPRISING TARGETED LIPOSOMAL THERAPEUTIC VACCINES DREXEL UNIVERSITY (US) 2026-04-30 WO disclosed
EP-4689670-A1 METHOD FOR IDENTIFYING REACTIVE OXYGEN SPECIES Centre National de la Recherche Scientifique (FR) 2026-02-11 EP disclosed
CN-120983453-A Application of small molecular antioxidant in slowing down vascular injury of type 2 diabetes 深圳市中佳生物医疗科技有限公司 2025-11-21 CN disclosed
WO-2025133028-A1 COMBINATION OF A BMP AND BMP2 L51P Universität Bern (CH) 2025-06-26 WO disclosed
EP-4574164-A1 COMBINATION OF A BMP AND BMP2 L51P Universität Bern (CH) 2025-06-25 EP disclosed
US-12266425-B1 T cell receptor sequences diagnostic for COVID-19 and related compositions ADAPTIVE BIOTECHNOLOGIES CORPORATION (US) 2025-04-01 US disclosed
WO-2024200474-A1 METHOD FOR IDENTIFYING REACTIVE OXYGEN SPECIES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2024-10-03 WO disclosed
EP-4439067-A1 METHOD FOR IDENTIFYING REACTIVE OXYGEN SPECIES Centre National de la Recherche Scientifique (FR) 2024-10-02 EP disclosed
US-20240294513-A1 PYRANONE COMPOUNDS USEFUL TO MODULATE OMA1 PROTEASE 712 NORTH INC. (US) 2024-09-05 US disclosed
US-11993590-B2 Pyranone compounds useful to modulate OMA1 protease 712 NORTH INC. (US) 2024-05-28 US disclosed
EP-4132577-A2 VACCINES, ADJUVANTS, AND METHODS OF GENERATING AN IMMUNE RESPONSE Eisai R&D Management Co., Ltd. (JP) 2023-02-15 EP disclosed
CN-112368280-B Heterocyclic derivatives as pest control agents 拜耳公司 2023-01-20 CN disclosed
CN-115146034-A Data balancing processing method based on syntactic analysis and synonym replacement technology 西安理工大学 2022-10-04 CN disclosed
CN-110505884-B Anti-cancer combination therapy 勃林格殷格翰国际有限公司 2022-08-12 CN disclosed
CN-114554887-A Smoking substitute system 聂鲁达有限公司 2022-05-27 CN disclosed
US-20220111004-A1 Combinatorial Apparatus for Disease Management MANYAK DAVID M (US) 2022-04-14 US disclosed
WO-2022039259-A1 METHOD FOR INDUCING IMMUNITY TO SARS-CoV-2 国立研究開発法人理化学研究所 2022-02-24 WO disclosed
CN-114072495-A Modified immune cells with enhanced antitumor activity and immunosuppressive resistance 比姆医疗股份有限公司 2022-02-18 CN disclosed
US-11179408-B2 Use of cyanoglucosides and pharmaceutical formulations thereof in the treatment of diabetes UNIVERSITÉ DE GENÈVE (CH) 2021-11-23 US disclosed
US-20190160085-A1 USE OF CYANOGLUCOSIDES AND PHARMACEUTICAL FORMULATIONS THEREOF IN THE TREATMENT OF DIABETES UNIVERSIDADE ESTADUAL PAULISTA JULIO DE MESQUITA FILHO (BR) 2019-05-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240294513-A1 PYRANONE COMPOUNDS USEFUL TO MODULATE OMA1 PROTEASE PITRM1, OPA1, HTRA2 MAPT 2058/4885PTPN1 4484/4885L3MBTL1 1875/4885
US-11993590-B2 Pyranone compounds useful to modulate OMA1 protease OPA1, OLA1, PITRM1 MAPT 641/4885PTPN1 3182/4885L3MBTL1 3927/4885
US-20190160085-A1 USE OF CYANOGLUCOSIDES AND PHARMACEUTICAL FORMULATIONS THEREOF IN THE TREATMENT OF DIABETES SLC5A1, SLC5A2, GYS2 MAPT 2428/4885PTPN1 3362/4885L3MBTL1 1912/4885
US-11179408-B2 Use of cyanoglucosides and pharmaceutical formulations thereof in the treatment of diabetes SLC5A2, SLC5A1, GYS2 MAPT 2343/4885PTPN1 3241/4885L3MBTL1 1839/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.