SCHEMBL2104420

SCHEMBL2104420

Cc1ccc(C(=O)Nc2cccc(C(=O)Cl)c2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 6/20 0.61
KMT2A Q03164 5/20 0.59
KCNK9 Q9NPC2 4/20 0.59
MEN1 O00255 4/20 0.59
KCNH2 Q12809 1/20 0.59
RXFP1 Q9HBX9 1/20 0.59
POLB P06746 2/20 0.59
RAB9A P51151 9/20 0.59
NPC1 O15118 8/20 0.59
CES1 P23141 1/20 0.59
SMN1; SMN2 Q16637 3/20 0.58
MAPT P10636 1/20 0.58
ALDH1A1 P00352 1/20 0.58
MET P08581 1/20 0.56
PTGS2 P35354 1/20 0.56
NR1H4 Q96RI1 1/20 0.56
TP53 P04637 1/20 0.55
NFKB1 P19838 1/20 0.55
NFKB2 Q00653 1/20 0.55
RELA Q04206 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2105158 0.88 KCNK3 (0.79) KCNK3KMT2AKCNK9MEN1KCNH2
SCHEMBL23513412 0.87 NPC1 (0.74) KCNK3KMT2AKCNK9MEN1KCNH2
SCHEMBL1359652 0.87 KCNK3 (0.76) KCNK3KMT2AKCNK9MEN1POLB
SCHEMBL12228168 0.87 RAB9A (0.71) KCNK3KMT2AKCNK9MEN1KCNH2
SCHEMBL2012930 0.86 KCNK3 (0.67) KCNK3KMT2AKCNK9MEN1POLB
SCHEMBL2076281 0.86 HPSE (0.72) KCNK3KMT2AKCNK9MEN1KCNH2
SCHEMBL7229995 0.85 RAB9A (0.65) POLBRAB9ANPC1SMN1; SMN2MAPT
Hydrochloric Acid SCHEMBL2104423 0.84 NR1H4 (0.70) KCNK3KMT2AKCNK9MEN1KCNH2
SCHEMBL2009691 0.84 MEN1 (0.76) KCNK3KMT2AKCNK9MEN1POLB
SCHEMBL19303149 0.84 KMT2A (0.59) KCNK3KMT2AKCNK9MEN1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230373947-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2023-11-23 US disclosed
US-11760742-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2023-09-19 US disclosed
US-20210230135-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2021-07-29 US disclosed
US-10995081-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2021-05-04 US disclosed
US-10435385-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2019-10-08 US disclosed
US-20180134681-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2018-05-17 US disclosed
US-9920026-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide MITSUI CHEMICALS, INC. (JP) 2018-03-20 US disclosed
EP-1714958-B9 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE MITSUI CHEMICALS AGRO INC (JP) 2017-05-31 EP disclosed
EP-1714958-B1 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE MITSUI CHEMICALS AGRO INC (JP) 2016-12-21 EP disclosed
US-20160002198-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE MITSUI CHEMICALS, INC. (JP) 2016-01-07 US disclosed
CN-1926094-B Amide derivatives, process for their preparation and their use as pesticides MITSUI CHEMICALS INC 2011-05-25 CN disclosed
CN-101906053-A Amide derivatives MITSUI CHEMICALS INC 2010-12-08 CN disclosed
US-20090192167-A1 Insecticidal and fungicidal composition MITSUI CHEMICALS, INC. (JP) 2009-07-30 US disclosed
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS MITSUI CHEMICALS, INC (JP) 2009-06-25 US disclosed
CN-101367748-A Amide derivatives, process for production of the same, and method for application thereof as insecticide MITSUI CHEMICALS INC (JP) 2009-02-18 CN disclosed
EP-1938685-A1 INSECTICIDAL AND BACTERICIDAL COMPOSITION Mitsui Chemicals, Inc. (JP) 2008-07-02 EP disclosed
EP-1913815-A1 PEST CONTROL COMPOSITION Mitsui Chemicals, Inc. (JP) 2008-04-23 EP disclosed
US-20070275980-A1 Amide Derivatives, Process For Preparation Thereof And Use Thereof As Insecticide MITSUI CHEMICALS, INC. (JP) 2007-11-29 US disclosed
CN-1926094-A Amide derivatives, process for their preparation and their use as pesticides MITSUI CHEMICALS INC (JP) 2007-03-07 CN disclosed
EP-1714958-A1 AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE Mitsui Chemicals, Inc. (JP) 2006-10-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070275980-A1 Amide Derivatives, Process For Preparation Thereof And Use Thereof As Insecticide CYP1A1, CYP4B1, CYP2E1 KCNK3 1494/4885KMT2A 1782/4885KCNK9 2801/4885
US-20180134681-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE CYP1A1, CYP4B1, CYP2E1 KCNK3 1494/4885KMT2A 1782/4885KCNK9 2801/4885
US-20160002198-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE CYP1A1, CYP4B1, CYP2E1 KCNK3 1494/4885KMT2A 1782/4885KCNK9 2801/4885
US-20090192167-A1 Insecticidal and fungicidal composition NOX3, PRDX1, CYP4X1 KCNK3 673/4885KMT2A 2083/4885KCNK9 1825/4885
US-20230373947-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 KCNK3 3042/4885KMT2A 565/4885KCNK9 1953/4885
US-20210230135-A1 AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE DDT, CYP4B1, CYP2E1 KCNK3 3042/4885KMT2A 565/4885KCNK9 1953/4885
US-10435385-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 KCNK3 3042/4885KMT2A 565/4885KCNK9 1953/4885
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS PRDX3, CYP1A1, GSTA1 KCNK3 2594/4885KMT2A 1594/4885KCNK9 3056/4885
US-11760742-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 KCNK3 3042/4885KMT2A 565/4885KCNK9 1953/4885
US-10995081-B2 Amide derivatives, process for preparation thereof and use thereof as insecticide DDT, CYP4B1, CYP2E1 KCNK3 3042/4885KMT2A 565/4885KCNK9 1953/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.