Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 3/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048771 | 0.81 | GLA (0.41) | PGRL3MBTL1KDM4EMAPK1POLB | |
| SCHEMBL31267493 | 0.79 | MAPT (0.55) | PGRTSHRPOLBMAPT | |
| SCHEMBL21048811 | 0.78 | CYP3A4 (0.47) | KEAP1CYP3A4CYP2C9CYP2C19TAS2R14 | |
| SCHEMBL17259042 | 0.72 | PGR (0.57) | KEAP1PGRTAS2R14NFE2L2L3MBTL1 | |
| SCHEMBL7829381 | 0.71 | MAPT (0.52) | KEAP1PGRTAS2R14NFE2L2TSHR | |
| SCHEMBL19848182 | 0.69 | KEAP1 (0.47) | KEAP1CYP3A4CYP2C9CYP2C19PGR | |
| SCHEMBL21734440 | 0.69 | KEAP1 (0.59) | KEAP1CYP2C9PGRTAS2R14NFE2L2 | |
| SCHEMBL19416820 | 0.68 | ALDH1A1 (0.60) | KEAP1PGRL3MBTL1KDM4EPOLB | |
| SCHEMBL7534915 | 0.68 | KDM4E (0.52) | KDM4EGAAMAPT | |
| SCHEMBL28802576 | 0.67 | MAOA (0.49) | CYP3A4CYP2C9CYP2C19PGRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |