Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048810 | 0.86 | GAA (0.47) | GAATP53SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL21048834 | 0.81 | TP53 (0.42) | GAATP53SMN1; SMN2MAPTEPHX2 | |
| SCHEMBL21048953 | 0.79 | LMNA (0.53) | SMN1; SMN2MAPTKEAP1NFE2L2 | |
| SCHEMBL21048892 | 0.77 | PTGER1 (0.50) | MAPTTSHRHPGDKEAP1NFE2L2 | |
| Hydrochloric Acid SCHEMBL21048912 | 0.76 | ADRA1A (0.41) | GAAALDH1A1HPGD | |
| SCHEMBL3594266 | 0.75 | MEN1 (0.47) | GAAHSD17B10MAPTEPHX2ALDH1A1 | |
| SCHEMBL20957057 | 0.75 | HSD17B10 (0.46) | GAATP53HSD17B10MAPTEPHX2 | |
| SCHEMBL3127214 | 0.74 | MEN1 (0.53) | GAAEPHX2ALDH1A1TSHRPKM | |
| SCHEMBL5968612 | 0.73 | EPHX2 (0.46) | GAAHSD17B10EPHX2ALDH1A1TSHR | |
| SCHEMBL17258888 | 0.73 | HSD17B10 (0.45) | GAAHSD17B10MAPTEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |