Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048953 | 0.86 | LMNA (0.53) | PTGER1APOBEC3AAPOBEC3GKEAP1NFE2L2 | |
| SCHEMBL21048810 | 0.86 | GAA (0.47) | TSHRPOLB | |
| SCHEMBL21048967 | 0.83 | MAPT (0.51) | PTGER1APOBEC3AAPOBEC3GKEAP1NFE2L2 | |
| Hydrochloric Acid SCHEMBL21048898 | 0.81 | KEAP1 (0.46) | KEAP1NFE2L2MAPTUSP2HPGD | |
| SCHEMBL21048778 | 0.77 | GAA (0.44) | KEAP1NFE2L2MAPTHPGDTSHR | |
| SCHEMBL21734725 | 0.76 | KEAP1 (0.60) | KEAP1NFE2L2MAPT | |
| SCHEMBL17258875 | 0.76 | KEAP1 (0.50) | KEAP1NFE2L2MAPTHPGD | |
| SCHEMBL21048817 | 0.74 | PGR (0.54) | PTGER1KEAP1NFE2L2MAPTHPGD | |
| SCHEMBL16557608 | 0.74 | KEAP1 (0.61) | KEAP1NFE2L2MAPTHPGDPOLB | |
| SCHEMBL15583912 | 0.71 | MAPT (0.70) | MAPTHPGDTSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |