Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24497502 | 0.81 | CYP19A1 (0.43) | KMT2AALDH1A1NPSR1 | |
| SCHEMBL21048778 | 0.81 | GAA (0.44) | TP53SMN1; SMN2EPHX2GAAALDH1A1 | |
| SCHEMBL17258893 | 0.78 | ALDH1A1 (0.53) | TP53KMT2AGAAALDH1A1TSHR | |
| SCHEMBL21048810 | 0.78 | GAA (0.47) | TP53SMN1; SMN2GAAALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL21048926 | 0.77 | CYP19A1 (0.41) | KMT2AGAAALDH1A1 | |
| SCHEMBL30005767 | 0.76 | KMT2A (0.48) | SMN1; SMN2KMT2AGAAALDH1A1NPC1 | |
| SCHEMBL3127214 | 0.76 | MEN1 (0.53) | EPHX2KMT2AGAAALDH1A1TAS1R3 | |
| SCHEMBL21048880 | 0.76 | ALDH1A1 (0.48) | KMT2AGAAALDH1A1NPC1NPSR1 | |
| SCHEMBL21048953 | 0.76 | LMNA (0.53) | SMN1; SMN2KMT2AMAPT | |
| SCHEMBL21048817 | 0.75 | PGR (0.54) | SMN1; SMN2KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |