Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | TYK2 | P29597 | 5/20 | 0.41 |
| ▸ | JAK3 | P52333 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048978 | 0.89 | TP53 (0.52) | PTGER1TP53JAK2JAK1TYK2 | |
| SCHEMBL21048813 | 0.84 | TP53 (0.41) | PTGER1TP53JAK2JAK1TYK2 | |
| SCHEMBL17258939 | 0.83 | TP53 (0.50) | PTGER1TP53JAK2JAK1TYK2 | |
| SCHEMBL28840926 | 0.81 | TP53 (0.48) | PTGER1TP53JAK2JAK1TYK2 | |
| SCHEMBL19337102 | 0.80 | ESR1 (0.40) | PTGER1JAK2JAK1TYK2JAK3 | |
| SCHEMBL17258893 | 0.77 | ALDH1A1 (0.53) | TP53JAK2GAAKMT2AHPGD | |
| SCHEMBL21048781 | 0.74 | C5AR1 (0.50) | PTGER1GAAKMT2AALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL21048812 | 0.74 | ESR1 (0.36) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL27682450 | 0.72 | ALDH1A1 (0.53) | GAAKMT2AHPGDALDH1A1HTT | |
| SCHEMBL21048855 | 0.72 | JAK2 (0.44) | PTGER1TP53JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |