Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | JAK1 | P23458 | 4/20 | 0.42 |
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17258939 | 0.89 | TP53 (0.50) | TP53NPC1RAB9APTGER1KMT2A | |
| SCHEMBL21048854 | 0.89 | PTGER1 (0.44) | TP53NPC1RAB9APTGER1KMT2A | |
| SCHEMBL28840926 | 0.87 | TP53 (0.48) | TP53NPC1RAB9APTGER1KMT2A | |
| SCHEMBL21048855 | 0.83 | JAK2 (0.44) | TP53NPC1RAB9APTGER1KMT2A | |
| SCHEMBL17258893 | 0.82 | ALDH1A1 (0.53) | TP53KMT2AMEN1JAK2ALDH1A1 | |
| SCHEMBL17258994 | 0.82 | ALDH1A1 (0.42) | TP53NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL21048808 | 0.82 | TP53 (0.44) | TP53NPC1RAB9APTGER1KMT2A | |
| SCHEMBL21048835 | 0.81 | JAK2 (0.44) | TP53NPC1RAB9APTGER1KMT2A | |
| SCHEMBL21048821 | 0.81 | ALDH1A1 (0.49) | TP53KMT2AMEN1JAK2JAK1 | |
| SCHEMBL19337065 | 0.80 | ALDH1A1 (0.47) | TP53KMT2AMEN1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |