Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048855 | 0.85 | JAK2 (0.44) | HTTJAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL21048830 | 0.81 | HTT (0.40) | HTTJAK2JAK1TYK2JAK3 | |
| SCHEMBL17258994 | 0.80 | ALDH1A1 (0.42) | HTTJAK2JAK1TYK2JAK3 | |
| SCHEMBL21048804 | 0.78 | JAK2 (0.41) | HTTJAK2JAK1TYK2JAK3 | |
| SCHEMBL22765684 | 0.71 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL20683120 | 0.71 | KMT2A (0.46) | ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL21048821 | 0.71 | ALDH1A1 (0.49) | HTTJAK2JAK1TYK2JAK3 | |
| SCHEMBL21048835 | 0.71 | JAK2 (0.44) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL21048914 | 0.71 | PTK2 (0.44) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL21048876 | 0.69 | PTK2 (0.43) | JAK2JAK1TYK2JAK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |