Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | JAK1 | P23458 | 6/20 | 0.46 |
| ▸ | TYK2 | P29597 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 6/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21048923 | 0.84 | PTK2 (0.49) | JAK2JAK1TYK2JAK3PTK2 | |
| Hydrochloric Acid SCHEMBL21048890 | 0.79 | JAK2 (0.38) | JAK2JAK1TYK2JAK3PTK2 | |
| SCHEMBL21048855 | 0.76 | JAK2 (0.44) | JAK2JAK1TYK2JAK3NPC1 | |
| SCHEMBL21048922 | 0.72 | EPHX2 (0.36) | NPC1RAB9AALDH1A1KDM4EGAA | |
| SCHEMBL21048978 | 0.70 | TP53 (0.52) | JAK2JAK1TYK2JAK3NPC1 | |
| SCHEMBL21048821 | 0.69 | ALDH1A1 (0.49) | JAK2JAK1TYK2JAK3POLB | |
| SCHEMBL21048871 | 0.69 | KDM4E (0.39) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL21048835 | 0.69 | JAK2 (0.44) | JAK2JAK1TYK2JAK3NPC1 | |
| Acetic Acid SCHEMBL1627880 | 0.66 | PTK2 (0.43) | JAK2JAK1TYK2JAK3PTK2 | |
| SCHEMBL21193073 | 0.64 | TRPM8 (0.36) | PTK2POLBTRPM8ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143021-B1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER (US) | 2019-06-12 | — | — | EP | disclosed |