SCHEMBL21055946

SCHEMBL21055946

C=Cc1c(Cl)cccc1Cl.C=Cc1cccc(F)c1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
RAB9A P51151 4/20 0.38
HPGD P15428 2/20 0.38
KMT2A Q03164 4/20 0.36
TDP1 Q9NUW8 2/20 0.36
MEN1 O00255 2/20 0.36
KCNH2 Q12809 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
MAT2A P31153 1/20 0.36
NFE2L2 Q16236 2/20 0.36
LMNA P02545 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
ALOX12 P18054 1/20 0.36
ATM Q13315 1/20 0.36
HTT P42858 3/20 0.35
MAPT P10636 2/20 0.35
MDM4 O15151 1/20 0.35
MDM2 Q00987 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29620247 0.84 NFE2L2 (0.44) ALDH1A1NFE2L2PTGS2
SCHEMBL466535 0.84 NFE2L2 (0.44) ALDH1A1NFE2L2PTGS2
SCHEMBL29700809 0.81 HPGD (0.47) ALDH1A1RAB9AHPGDKMT2ATDP1
SCHEMBL9245053 0.81 ALDH1A1 (0.60) ALDH1A1RAB9AHPGDKMT2ATDP1
SCHEMBL3339035 0.81 HPGD (0.47) ALDH1A1RAB9AHPGDKMT2ATDP1
SCHEMBL1207128 0.78 ALDH1A1 (0.62) ALDH1A1RAB9AHPGDKMT2ATDP1
SCHEMBL181965 0.78 ALDH1A1 (0.55) ALDH1A1RAB9AHPGDKMT2ATDP1
SCHEMBL27920138 0.76 ALDH1A1 (0.52) ALDH1A1RAB9AHPGDKMT2ATDP1
SCHEMBL16933848 0.74 NFE2L2 (0.50) ALDH1A1RAB9AHPGDKCNH2MAT2A
SCHEMBL574172 0.73 ALDH1A1 (0.46) ALDH1A1KMT2ATDP1MEN1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4127039-A1 HIGH DARKNESS AND HIGH GLOSS DIMENSIONALLY STABLE THERMOPLASTIC SMMA MOLDING COMPOSITION INEOS Styrolution Group GmbH (DE) 2023-02-08 EP disclosed
WO-2021198528-A1 HIGH DARKNESS AND HIGH GLOSS DIMENSIONALLY STABLE THERMOPLASTIC SMMA MOLDING COMPOSITION INEOS STYROLUTION GROUP GMBH (DE) 2021-10-07 WO disclosed
EP-3105267-B1 USE OF METHYL METHACRYLATE VINYLAROMATE COPOLYMERS INEOS STYROLUTION GROUP GMBH (DE) 2019-06-19 EP disclosed