Sugi Predict

Sugi Predict / Compounds / SCHEMBL21057955

SCHEMBL21057955

SCHEMBL21057955

COC(=O)C1CC(=O)NC1c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2D6 P10635 2/20 0.50
▸ LMNA P02545 1/20 0.47
▸ ALDH1A1 P00352 2/20 0.45
▸ TDP1 Q9NUW8 1/20 0.45
▸ SLC6A2 P23975 2/20 0.45
▸ SLC6A4 P31645 2/20 0.45
▸ SLC6A3 Q01959 2/20 0.45
▸ TSHR P16473 2/20 0.44
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ KDM4E B2RXH2 1/20 0.44
▸ GAA P10253 1/20 0.43
▸ POLB P06746 1/20 0.43
▸ CA1 P00915 1/20 0.43
▸ CA2 P00918 1/20 0.43
▸ CA4 P22748 1/20 0.43
▸ CA7 P43166 1/20 0.43
▸ CYP1A2 P05177 2/20 0.42
▸ HSD17B10 Q99714 2/20 0.42
▸ CYP3A4 P08684 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21057760 0.85 RECQL (0.46) ALDH1A1SLC6A2SLC6A4SLC6A3POLB
SCHEMBL30406123 0.85 CYP2D6 (0.48) CYP2D6LMNAALDH1A1TDP1SLC6A2
SCHEMBL1556406 0.84 MAPT (0.51) CYP2D6LMNAALDH1A1TSHRMEN1
SCHEMBL21057764 0.84 ALDH1A1 (0.45) ALDH1A1TSHRKDM4EGAAPOLB
SCHEMBL21057657 0.84 ALDH1A1 (0.46) LMNAALDH1A1TDP1MEN1KMT2A
SCHEMBL24378247 0.84 ALDH1A1 (0.45) ALDH1A1TSHRKDM4EGAAPOLB
SCHEMBL21057816 0.84 TP53 (0.44) ALDH1A1SLC6A3TSHRGAAHSD17B10
SCHEMBL21057931 0.82 LMNA (0.40) LMNAALDH1A1MEN1KMT2AGAA
SCHEMBL21057926 0.82 LMNA (0.40) LMNAALDH1A1MEN1KMT2AGAA
SCHEMBL21057929 0.82 LMNA (0.40) LMNAALDH1A1MEN1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12540130-B2 Substituted pyrrolidine amides IV GRUENENTHAL GMBH (DE) 2026-02-03 — — US disclosed
US-12522586-B2 Substituted pyrrolidine amines and amides VI GRUENENTHAL GMBH (DE) 2026-01-13 — — US disclosed
EP-4178954-B1 SUBSTITUTED PYRROLIDINE AMINES AND AMIDES AS MEDIATOR OF THE GLUCOCORTOID RECEPTOR GRUENENTHAL GMBH (DE) 2025-11-19 — — EP disclosed
US-12358907-B2 Substituted pyrrolidine amides III Grünenthal GmbH (DE) 2025-07-15 — — US disclosed
US-12344605-B2 Substituted pyrrolidine amides II GRUENENTHAL GMBH (DE) 2025-07-01 — — US disclosed
US-12331034-B2 Substituted pyrrolidine amides V GRUENENTHAL GMBH (DE) 2025-06-17 — — US disclosed
CN-113382990-B Substituted pyrrolidinamide III 格吕伦塔尔有限公司 2024-11-19 — — CN disclosed
US-20230265078-A1 SUBSTITUTED PYRROLIDINE AMINES AND AMIDES VI GRUENENTHAL GMBH (DE) 2023-08-24 — — US disclosed
US-20230265078-A1 SUBSTITUTED PYRROLIDINE AMINES AND AMIDES VI GRUENENTHAL GMBH (DE) 2023-08-24 — — US disclosed
EP-4178954-A1 SUBSTITUTED PYRROLIDINE AMINES AND AMIDES AS MEDIATOR OF THE GLUCOCORTOID RECEPTOR Grünenthal GmbH (DE) 2023-05-17 — — EP disclosed
CN-111556867-A Substituted pyrrolidine amides I 格吕伦塔尔有限公司 2020-08-18 — — CN disclosed
CN-111491931-A Substituted pyrrolidine amides II 格吕伦塔尔有限公司 2020-08-04 — — CN disclosed
US-20200223840-A1 SUBSTITUTED PYRROLIDINE AMIDES III GRUENENTHAL GMBH (DE) 2020-07-16 — — US disclosed
US-20200223840-A1 SUBSTITUTED PYRROLIDINE AMIDES III GRUENENTHAL GMBH (DE) 2020-07-16 — — US disclosed
WO-2020144375-A1 SUBSTITUTED PYRROLIDINE AMIDES III Grünenthal GmbH (DE) 2020-07-16 — — WO disclosed
US-10626106-B2 Substituted pyrrolidine amides I GRUENENTHAL GMBH (DE) 2020-04-21 — — US disclosed
US-20190185470-A1 Substituted Pyrrolidine Amides II GRUENENTHAL GMBH (DE) 2019-06-20 — — US disclosed
US-20190185470-A1 Substituted Pyrrolidine Amides II GRUENENTHAL GMBH (DE) 2019-06-20 — — US disclosed
US-20190185455-A1 Substituted Pyrrolidine Amides I GRUENENTHAL GMBH (DE) 2019-06-20 — — US disclosed
US-20190185455-A1 Substituted Pyrrolidine Amides I GRUENENTHAL GMBH (DE) 2019-06-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12358907-B2 Substituted pyrrolidine amides III NR3C1, NR3C2, MC2R CYP2D6 490/4885LMNA 4699/4885ALDH1A1 1199/4885
US-20200223840-A1 SUBSTITUTED PYRROLIDINE AMIDES III NR3C1, NR3C2, MC2R CYP2D6 490/4885LMNA 4699/4885ALDH1A1 1199/4885
US-20190185470-A1 Substituted Pyrrolidine Amides II NR3C1, NR3C2, MC2R CYP2D6 474/4885LMNA 4704/4885ALDH1A1 1258/4885
US-10626106-B2 Substituted pyrrolidine amides I NR3C1, NR3C2, NR5A1 CYP2D6 485/4885LMNA 4685/4885ALDH1A1 814/4885
US-12540130-B2 Substituted pyrrolidine amides IV NR3C1, NR3C2, CRHR1 CYP2D6 153/4885LMNA 3772/4885ALDH1A1 1019/4885
US-12331034-B2 Substituted pyrrolidine amides V NR3C1, NR3C2, MC2R CYP2D6 415/4885LMNA 4663/4885ALDH1A1 1264/4885
US-12344605-B2 Substituted pyrrolidine amides II NR3C1, NR3C2, MC2R CYP2D6 474/4885LMNA 4704/4885ALDH1A1 1258/4885
US-20230265078-A1 SUBSTITUTED PYRROLIDINE AMINES AND AMIDES VI NR3C1, MC2R, NR3C2 CYP2D6 217/4885LMNA 4500/4885ALDH1A1 1331/4885
US-20190185455-A1 Substituted Pyrrolidine Amides I NR3C1, NR3C2, NR5A1 CYP2D6 485/4885LMNA 4685/4885ALDH1A1 814/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.