Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567713 | 0.85 | ALDH1A1 (0.44) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL11711947 | 0.76 | KDM4E (0.47) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL27619838 | 0.73 | KMT2A (0.43) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL3582727 | 0.70 | GSK3A (0.50) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL3581778 | 0.70 | ALDH1A1 (0.43) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL6280747 | 0.69 | KDM4E (0.45) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL16888062 | 0.67 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL3590708 | 0.66 | ALDH1A1 (0.43) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL4591705 | 0.66 | KDM4E (0.56) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL23212090 | 0.66 | PKM (0.34) | KMT2AALDH1A1KDM4ELMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810094-A1 | TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A JAK OR OTHER KINASE INHIBITOR | Progenity, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3810095-A1 | TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A TNF INHIBITOR | Progenity, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| WO-2021067313-A1 | EUKARYOTIC SEMI-SYNTHETIC ORGANISMS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-04-08 | — | — | WO | disclosed |
| EP-3723801-A1 | TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A S1P MODULATOR | Progenity, Inc. (US) | 2020-10-21 | — | — | EP | disclosed |
| WO-2019118778-A1 | TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A S1P MODULATOR | PROGENITY, INC. (US) | 2019-06-20 | — | — | WO | disclosed |