Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21063452 | 0.85 | GPR119 (0.52) | DDB1CRBNRORCGPR119USP30 | |
| SCHEMBL29220941 | 0.84 | USP30 (0.46) | DDB1CRBNRORCGPR119USP30 | |
| SCHEMBL25255965 | 0.84 | DDB1 (0.46) | DDB1CRBNRORCGPR119KDM4E | |
| SCHEMBL30396142 | 0.84 | DDB1 (0.46) | DDB1CRBNRORCGPR119KDM4E | |
| SCHEMBL31639929 | 0.82 | DDB1 (0.47) | DDB1CRBNRORCGPR119KDM4E | |
| SCHEMBL22059965 | 0.81 | RORC (0.46) | DDB1CRBNRORCGPR119KDM4E | |
| SCHEMBL20757383 | 0.81 | DDB1 (0.46) | DDB1CRBNRORCGPR119KDM4E | |
| SCHEMBL255458 | 0.81 | DDB1 (0.46) | DDB1CRBNRORCGPR119KDM4E | |
| SCHEMBL24989018 | 0.81 | DDB1 (0.46) | DDB1CRBNRORCGPR119USP30 | |
| SCHEMBL255448 | 0.81 | ALOX5AP (0.47) | DDB1CRBNRORCUSP30KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118612-A1 | TARGETING COMPOUNDS | ZAFGEN, INC. (US) | 2019-06-20 | — | — | WO | disclosed |