Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.30 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.30 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.30 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.30 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.30 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30605554 | 0.86 | APP (0.39) | LMNAPTGS1PDE4ASLC6A6CYP2C19 | |
| SCHEMBL10511006 | 0.81 | LMNA (0.35) | LMNAPTGS1PDE4ASLC6A6CYP2C19 | |
| SCHEMBL2169002 | 0.77 | GABRA5 (0.46) | LMNAITGB3ITGA2BF2RGABRA5 | |
| SCHEMBL8078390 | 0.77 | — | — | |
| SCHEMBL24393115 | 0.76 | APLNR (0.30) | — | |
| Hydrochloric Acid SCHEMBL29891111 | 0.76 | GABRA5 (0.45) | LMNAITGB3ITGA2BF2RGABRA5 | |
| SCHEMBL27891333 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL6199423 | 0.73 | INPP5A (0.48) | LMNAGABRA5SLC6A1GABRB2SLC6A12 | |
| SCHEMBL9320849 | 0.73 | PTGS1 (0.36) | LMNAPTGS1PDE4ASLC6A6CYP2C19 | |
| SCHEMBL4072061 | 0.73 | ALDH1A1 (0.37) | LMNAPTGS1PDE4ASLC6A6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118612-A1 | TARGETING COMPOUNDS | ZAFGEN, INC. (US) | 2019-06-20 | — | — | WO | disclosed |
| WO-2019118612-A1 | TARGETING COMPOUNDS | ZAFGEN, INC. (US) | 2019-06-20 | — | — | WO | disclosed |