Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | TACR3 | P29371 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20004193 | 0.82 | GRM5 (0.43) | GRM5NAMPTGPR183JAK2JAK1 | |
| SCHEMBL21078112 | 0.80 | HPGD (0.42) | GRM5NAMPTJAK2JAK1ALDH1A1 | |
| SCHEMBL21077918 | 0.77 | ALDH1A1 (0.48) | NAMPTKMT2AALDH1A1TSHR | |
| SCHEMBL21078144 | 0.77 | KEAP1 (0.44) | GRM5NAMPTKMT2AALDH1A1TSHR | |
| SCHEMBL21077851 | 0.77 | JAK1 (0.35) | GRM5NAMPTJAK2JAK1ALDH1A1 | |
| SCHEMBL21078098 | 0.76 | CHRNB2 (0.41) | GRM5JAK2JAK1ALDH1A1GAA | |
| SCHEMBL21077905 | 0.76 | ALDH1A1 (0.52) | NAMPTKMT2AALDH1A1TSHR | |
| SCHEMBL21077917 | 0.74 | NAMPT (0.48) | GRM5NAMPTGPR183ALDH1A1KDM4E | |
| SCHEMBL21078133 | 0.73 | L3MBTL1 (0.38) | GRM5NAMPTKMT2ACCNT1CDK9 | |
| SCHEMBL23210600 | 0.73 | GPR183 (0.38) | GRM5GPR183NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |