Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 3/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 6/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 6/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 6/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21078126 | 0.86 | JAK2 (0.35) | JAK2JAK1ADAM10ERBB2MMP2 | |
| SCHEMBL21078147 | 0.84 | ADAM10 (0.40) | JAK2JAK1ADAM10MMP2MMP9 | |
| SCHEMBL17888263 | 0.81 | HRH3 (0.38) | PRSS1F2TPSAB1TPSD1TPSG1 | |
| SCHEMBL21077854 | 0.79 | MAPT (0.43) | — | |
| SCHEMBL17886601 | 0.78 | PDK4 (0.35) | PRSS1F2TPSAB1TPSD1TPSG1 | |
| SCHEMBL21078133 | 0.78 | L3MBTL1 (0.38) | — | |
| SCHEMBL21077987 | 0.77 | PRSS1 (0.38) | PRSS1TPSAB1TPSD1TPSG1JAK2 | |
| SCHEMBL19226371 | 0.77 | HRH3 (0.41) | HRH3 | |
| SCHEMBL14243052 | 0.75 | TPSAB1 (0.42) | PRSS1F2TPSAB1TPSD1TPSG1 | |
| SCHEMBL21078112 | 0.75 | HPGD (0.42) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |