Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25809625 | 0.88 | TP53 (0.47) | HSD11B1TP53CYP1A2CYP2C19LMNA | |
| SCHEMBL18675984 | 0.80 | SLC18A3 (0.47) | TP53CYP1A2LMNAMAPTALDH1A1 | |
| SCHEMBL24315732 | 0.79 | CYP11B2 (0.54) | HSD11B1SPRLMNAMAPTALDH1A1 | |
| SCHEMBL18675979 | 0.77 | RAB9A (0.45) | CYP1A2CYP2C19MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7705153 | 0.77 | HTR1A (0.43) | HSD11B1TP53 | |
| SCHEMBL27934928 | 0.77 | HSD11B1 (0.43) | HSD11B1TP53MAP4K4SPRCYP1A2 | |
| SCHEMBL17886516 | 0.77 | TP53 (0.46) | HSD11B1TP53MAP4K4SPRCYP1A2 | |
| SCHEMBL19116791 | 0.74 | DRD2 (0.45) | HRH3 | |
| SCHEMBL12026532 | 0.73 | PDE9A (0.45) | HSD11B1TP53MAP4K4SPRHRH3 | |
| SCHEMBL13783764 | 0.73 | PDE4B (0.48) | HSD11B1TP53MAP4K4SPRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |