Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KMO | O15229 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30444177 | 0.92 | KDM1A (0.54) | PPM1DHIF1AEPHX1KDM1AMEP1B | |
| SCHEMBL9057020 | 0.89 | POLB (0.54) | PPM1DPOLBHDAC1ALDH1A1CYP2D6 | |
| SCHEMBL791813 | 0.86 | THRB (0.51) | PPM1DHIF1AKDM1AMEP1BFOLH1 | |
| SCHEMBL15830232 | 0.86 | PRMT5 (0.51) | PPM1DKMOHIF1AKDM1AMEP1B | |
| SCHEMBL14032272 | 0.84 | KDM1A (0.48) | PPM1DALDH1A1EPHX1KDM1AMEP1B | |
| SCHEMBL30443983 | 0.82 | KDM1A (0.51) | PPM1DHIF1AKDM1AMEP1BFOLH1 | |
| SCHEMBL9252404 | 0.82 | ALDH1A1 (0.68) | POLBHDAC1ALDH1A1CXCR4HRH3 | |
| SCHEMBL11509945 | 0.82 | ALDH1A1 (0.68) | POLBHDAC1ALDH1A1CXCR4HRH3 | |
| SCHEMBL21089268 | 0.81 | HDAC1 (0.72) | POLBHDAC1ALDH1A1TAAR1EPHX1 | |
| SCHEMBL6911153 | 0.79 | ALDH1A1 (0.51) | POLBALDH1A1EPHX1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286172-B1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2019-06-12 | — | — | EP | disclosed |