Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21088529 | 0.92 | ALDH1A1 (0.43) | TSHRUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18182858 | 0.81 | TSHR (0.40) | TSHRUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21089303 | 0.76 | KDM4E (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL18183055 | 0.74 | KDM1A (0.40) | TSHRUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21088526 | 0.74 | OPRM1 (0.39) | TSHRUSP2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2624494 | 0.73 | L3MBTL1 (0.59) | TSHRMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL15033008 | 0.73 | ALDH1A1 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL21088568 | 0.72 | CYP2D6 (0.46) | TSHRUSP2SMN1; SMN2CYP2D6ALDH1A1 | |
| SCHEMBL23652681 | 0.72 | OPRM1 (0.41) | TSHRSMN1; SMN2MEN1KMT2ACYP2D6 | |
| SCHEMBL21088397 | 0.71 | USP2 (0.36) | TSHRUSP2SMN1; SMN2CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286172-B1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2019-06-12 | — | — | EP | disclosed |