Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16095734 | 0.90 | LMNA (0.45) | LMNAKMT2APOLBSMN1; SMN2PKM | |
| SCHEMBL21097015 | 0.81 | LMNA (0.46) | LMNAKMT2APOLBSMN1; SMN2PKM | |
| SCHEMBL28231420 | 0.80 | SMN1; SMN2 (0.48) | LMNAKMT2APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL26254874 | 0.79 | KMT2A (0.49) | LMNAKMT2APOLBSMN1; SMN2PKM | |
| SCHEMBL2757954 | 0.79 | KMT2A (0.56) | LMNAKMT2APOLBSMN1; SMN2PKM | |
| SCHEMBL2146193 | 0.77 | LMNA (0.45) | LMNAKMT2APOLBSMN1; SMN2PKM | |
| SCHEMBL2757960 | 0.77 | MAPK8 (0.43) | LMNAKMT2APOLBSMN1; SMN2PKM | |
| SCHEMBL15798061 | 0.77 | ITGB3 (0.36) | LMNAKMT2APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL21995651 | 0.77 | ITGB3 (0.36) | LMNAKMT2APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL844932 | 0.77 | LMNA (0.43) | LMNAKMT2APOLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |