SCHEMBL21099137

SCHEMBL21099137

CC(C)(C)[Si](C)(C)O[C@@H](Cc1ccccc1)C(N)=O

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SRR Q9GZT4 3/20 0.47
EPHX1 P07099 1/20 0.44
PPARG P37231 11/20 0.41
PPARA Q07869 10/20 0.41
PSAT1 Q9Y617 1/20 0.40
ALPI P09923 1/20 0.40
PKM P14618 1/20 0.40
PTGS1 P23219 1/20 0.40
XIAP P98170 1/20 0.40
SLC7A5 Q01650 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8823359 0.88 SRR (0.54) SRRPPARGPPARA
SCHEMBL1595266 0.88 SRR (0.54) SRRPPARGPPARA
SCHEMBL27786693 0.87 SRR (0.45) SRRPPARGPPARAALPIPKM
SCHEMBL8823316 0.85 SRR (0.44) SRRPPARGPPARA
SCHEMBL4406213 0.85 LDHA (0.48) EPHX1PPARGPPARA
SCHEMBL12755046 0.84 ATM (0.44) SRRPPARGPPARA
SCHEMBL11202582 0.84 SRR (0.43) SRRPPARGPPARA
SCHEMBL1667087 0.82 FAAH (0.44) PPARGPPARA
SCHEMBL2163274 0.81 FAAH (0.46)
SCHEMBL6740375 0.78 PPARG (0.63) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11673869-B2 4-oxazolidinone antimicrobial agents NORTH CAROLINA STATE UNIVERSITY (US) 2023-06-13 US disclosed
US-11673869-B2 4-oxazolidinone antimicrobial agents NORTH CAROLINA STATE UNIVERSITY (US) 2023-06-13 US disclosed
US-20210323934-A1 4-OXAZOLIDINONE ANTIMICROBIAL AGENTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-10-21 US disclosed
US-10844025-B2 4-oxazolidinone antimicrobial agents NORTH CAROLINA STATE UNIVERSITY (US) 2020-11-24 US disclosed
US-20190177285-A1 4-OXAZOLIDINONE ANTIMICROBIAL AGENTS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2019-06-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190177285-A1 4-OXAZOLIDINONE ANTIMICROBIAL AGENTS OXA1L, MMP17, MMP2 SRR 3871/4885EPHX1 4072/4885PPARG 1907/4885
US-10844025-B2 4-oxazolidinone antimicrobial agents OXA1L, MMP17, MMP2 SRR 3871/4885EPHX1 4072/4885PPARG 1907/4885
US-11673869-B2 4-oxazolidinone antimicrobial agents OXA1L, MMP17, MMP2 SRR 3871/4885EPHX1 4072/4885PPARG 1907/4885
US-20210323934-A1 4-OXAZOLIDINONE ANTIMICROBIAL AGENTS OXA1L, MMP17, MMP2 SRR 3871/4885EPHX1 4072/4885PPARG 1907/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.