Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21102124 | 0.84 | RXRA (0.38) | MEN1KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL21101912 | 0.80 | TACR1 (0.35) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21101918 | 0.74 | TACR1 (0.37) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16560482 | 0.70 | CA2 (0.39) | TACR1HTTCYP1A2CYP2C19 | |
| SCHEMBL21101764 | 0.69 | CTSD (0.42) | KMT2AKDM4E | |
| SCHEMBL21102128 | 0.69 | GLS (0.44) | MEN1KMT2AMAPT | |
| SCHEMBL21101917 | 0.66 | KDM4E (0.55) | MEN1KMT2AMAPTKDM4EALOX12 | |
| SCHEMBL21101913 | 0.65 | MEN1 (0.34) | TACR1CYP2D6MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL6208799 | 0.64 | TACR1 (0.52) | TACR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8640586 | 0.63 | TACR1 (0.55) | TACR1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |