Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.65 |
| ▸ | MAPT | P10636 | 9/20 | 0.65 |
| ▸ | GAA | P10253 | 7/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21114859 | 1.00 | ALDH1A1 (0.65) | ALDH1A1MAPTGAARAB9AL3MBTL1 | |
| SCHEMBL22529442 | 0.98 | MAPT (0.66) | ALDH1A1MAPTGAARAB9AL3MBTL1 | |
| SCHEMBL22529440 | 0.98 | MAPT (0.66) | ALDH1A1MAPTGAARAB9AL3MBTL1 | |
| SCHEMBL22529444 | 0.97 | ALDH1A1 (0.60) | ALDH1A1MAPTGAARAB9AL3MBTL1 | |
| SCHEMBL22529447 | 0.97 | ALDH1A1 (0.60) | ALDH1A1MAPTGAARAB9AL3MBTL1 | |
| SCHEMBL21114872 | 0.83 | MAPT (0.65) | ALDH1A1MAPTGAARAB9AL3MBTL1 | |
| SCHEMBL21114874 | 0.83 | MAPT (0.65) | ALDH1A1MAPTGAARAB9AL3MBTL1 | |
| SCHEMBL4238950 | 0.83 | GAA (0.65) | ALDH1A1MAPTGAARAB9AL3MBTL1 | |
| SCHEMBL4238951 | 0.83 | GAA (0.65) | ALDH1A1MAPTGAARAB9AL3MBTL1 | |
| SCHEMBL13693824 | 0.83 | GAA (0.65) | ALDH1A1MAPTGAARAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114173780-A | Compounds for reducing the deleterious activity of genes containing extended nucleotide repeats | 小利兰·斯坦福大学托管委员会 | 2022-03-11 | — | — | CN | disclosed |
| US-10882821-B1 | Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2021-01-05 | — | — | US | disclosed |
| US-10736911-B2 | Use of a DHODH inhibitor in combination with an inhibitor of pyrimidine salvage | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2020-08-11 | — | — | US | disclosed |
| US-10736911-B2 | Use of a DHODH inhibitor in combination with an inhibitor of pyrimidine salvage | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2020-08-11 | — | — | US | disclosed |
| US-20190209598-A1 | USE OF A DHODH INHIBITOR IN COMBINATION WITH AN INHIBITOR OF PYRIMIDINE SALVAGE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2019-07-11 | — | — | US | disclosed |
| US-20190209598-A1 | USE OF A DHODH INHIBITOR IN COMBINATION WITH AN INHIBITOR OF PYRIMIDINE SALVAGE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190209598-A1 | USE OF A DHODH INHIBITOR IN COMBINATION WITH AN INHIBITOR OF PYRIMIDINE SALVAGE | DHODH, DPYD, DHPS | ALDH1A1 502/4885MAPT 3576/4885GAA 1822/4885 |
| US-10882821-B1 | Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes | NSUN2, RRM2B, RNMT | ALDH1A1 2751/4885MAPT 3576/4885GAA 1481/4885 |
| US-10736911-B2 | Use of a DHODH inhibitor in combination with an inhibitor of pyrimidine salvage | DHODH, DPYD, DHPS | ALDH1A1 502/4885MAPT 3576/4885GAA 1822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.