Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2681462 | 0.85 | MAPT (0.78) | MAPTGPR35CA12CA1CA2 | |
| SCHEMBL11052381 | 0.84 | MAPT (0.54) | MAPTGPR35CA12CA1CA2 | |
| SCHEMBL12347771 | 0.83 | MAPT (0.69) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL15946352 | 0.82 | EPHX2 (0.72) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL7951394 | 0.81 | MAPT (1.00) | MAPTGPR35CA12CA1CA2 | |
| SCHEMBL17849580 | 0.81 | MEN1 (0.60) | MAPTLMNAMEN1NPC1RAB9A | |
| SCHEMBL12404443 | 0.79 | SMN1; SMN2 (0.71) | MAPTGPR35LMNAMEN1KMT2A | |
| SCHEMBL13805295 | 0.78 | MAPT (0.63) | MAPTGPR35CA12CA1CA2 | |
| SCHEMBL7520231 | 0.78 | ALDH1A1 (0.70) | MAPTGPR35CA12CA1CA2 | |
| SCHEMBL23148069 | 0.78 | MAPT (0.62) | MAPTGPR35P2RX1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793527-B2 | Adenosine monophosphate-activated protein kinase agonist | NATIONAL YANG-MING UNIVERSITY (TW) | 2020-10-06 | — | — | US | disclosed |
| US-20190194142-A1 | AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST | NATIONAL YANG-MING UNIVERSITY (TW) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194142-A1 | AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST | PRKAG1, PRKAG2, PRKAB1 | MAPT 4049/4885GPR35 1032/4885CA12 4872/4885 |
| US-10793527-B2 | Adenosine monophosphate-activated protein kinase agonist | PRKAG1, PRKAG2, PRKAB1 | MAPT 4022/4885GPR35 875/4885CA12 4868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.