Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.39 |
| ▸ | RAB9A | P51151 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21116162 | 0.85 | KDM4E (0.38) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL26854645 | 0.84 | KLK7 (0.42) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL24046232 | 0.80 | MIF (0.36) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL23713490 | 0.80 | MIF (0.40) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL18535561 | 0.80 | KDM4E (0.46) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL21116032 | 0.78 | THRB (0.38) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL27105690 | 0.78 | KLK7 (0.41) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL18535568 | 0.78 | RAB9A (0.40) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL27105750 | 0.74 | THRB (0.40) | NPC1RAB9AKDM4EHPGDALDH1A1 | |
| SCHEMBL18535493 | 0.74 | GLA (0.67) | NPC1RAB9AKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3502147-A1 | COMPOSITION FOR OPHTHALMOLOGICAL PRODUCTS | Merck Patent GmbH (DE) | 2019-06-26 | — | — | EP | disclosed |