Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21251228 | 0.91 | CNR2 (0.38) | SMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL21157291 | 0.88 | EED (0.43) | SMN1; SMN2LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL21157283 | 0.88 | ALOX15 (0.41) | SMN1; SMN2LMNARAB9AMAPTTSHR | |
| SCHEMBL21113204 | 0.87 | RAB9A (0.42) | SMN1; SMN2LMNARAB9AMAPTNPC1 | |
| SCHEMBL21156531 | 0.86 | ALDH1A1 (0.40) | SMN1; SMN2LMNAALDH1A1KDM4E | |
| SCHEMBL21156593 | 0.86 | EZH2 (0.38) | SMN1; SMN2LMNAMAPK1RAB9AMAPT | |
| SCHEMBL21156559 | 0.84 | EED (0.50) | HRH3 | |
| SCHEMBL19964426 | 0.84 | NPC1 (0.41) | SMN1; SMN2LMNAMAPK1MAPTNPC1 | |
| SCHEMBL21157327 | 0.84 | PRKCZ (0.42) | SMN1; SMN2LMNARAB9AMAPTNPC1 | |
| SCHEMBL21156563 | 0.82 | ALDH1A1 (0.35) | SMN1; SMN2LMNAMAPK1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109790160-B | Pyrido five-membered aromatic ring compound, preparation method and application thereof | 上海海和药物研究开发股份有限公司 | 2022-11-15 | — | — | CN | disclosed |
| US-10968215-B2 | Pyrido five-element aromatic ring compound, preparation method therefor and use thereof | SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) | 2021-04-06 | — | — | US | disclosed |
| US-20190211010-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | HAIHE BIOPHARMA CO. LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968215-B2 | Pyrido five-element aromatic ring compound, preparation method therefor and use thereof | EZH2, IKZF2, SUZ12 | HRH3 1167/4885ENPP2 1548/4885SMN1; SMN2 4308/4885 |
| US-20190211010-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | EZH2, IKZF2, SUZ12 | HRH3 1167/4885ENPP2 1548/4885SMN1; SMN2 4308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.