Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21159434 | 0.84 | MAP4K4 (0.34) | MAPTSMN1; SMN2 | |
| SCHEMBL21159595 | 0.67 | RAB9A (0.38) | HTTRAB9AGALR3MAPTKDM4C | |
| SCHEMBL19917080 | 0.67 | ADORA3 (0.49) | HTTADORA3ADORA2AADORA1RAB9A | |
| SCHEMBL8856262 | 0.66 | HTT (0.42) | HTTRAB9AGALR3MAPTGAA | |
| SCHEMBL5248227 | 0.66 | EGFR (0.38) | HTTLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL31058885 | 0.65 | KDM4C (0.38) | HTTADORA3ADORA2AADORA1PKM | |
| SCHEMBL25680390 | 0.65 | KDM4C (0.38) | HTTADORA3ADORA2AADORA1PKM | |
| SCHEMBL5244332 | 0.65 | EGFR (0.53) | MAPTKMT2A | |
| SCHEMBL41301 | 0.64 | — | — | |
| SCHEMBL21159117 | 0.64 | NUDT1 (0.35) | HTTMAPTKDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505171-A1 | BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2019-07-03 | — | — | EP | disclosed |