Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2126 | 0.84 | SCN1A (0.48) | SCN1ASCN2ASCN3ALTB4R2PDE7A | |
| SCHEMBL2117 | 0.77 | SCN1A (0.45) | FOLH1SCN1ASCN2ASCN3ALTB4R | |
| SCHEMBL3201 | 0.77 | SCN1A (0.49) | SCN1ASCN2ASCN3ALTB4R2PDE7A | |
| SCHEMBL3431159 | 0.76 | FOLH1 (0.53) | FOLH1SCN1ASCN2ASCN3ALTB4R | |
| SCHEMBL9407400 | 0.74 | FOLH1 (0.75) | FOLH1LTB4RLTB4R2PTPN2PTPN1 | |
| SCHEMBL2301 | 0.73 | SCN1A (0.47) | SCN1ASCN2ASCN3AKMT2ANPC1 | |
| SCHEMBL3019 | 0.71 | ADRB3 (0.42) | SCN1ASCN2ASCN3ALTB4R2PDCD1 | |
| SCHEMBL1614 | 0.70 | SCN1A (0.47) | SCN1ASCN2ASCN3ANPC1DRD3 | |
| SCHEMBL534889 | 0.69 | KDM4E (0.50) | FOLH1LTB4RLTB4R2KMT2APDCD1 | |
| SCHEMBL10512148 | 0.69 | LOXL2 (0.51) | FOLH1KMT2APDCD1CD274MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |