Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | MYC | P01106 | 6/20 | 1.00 |
| ▸ | POLB | P06746 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 1.00 |
| ▸ | NR4A1 | P22736 | 2/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | PTPN7 | P35236 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 2/20 | 0.74 |
| ▸ | APEX1 | P27695 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17172463 | 0.89 | POLB (0.79) | KDM4EALDH1A1MYCPOLBMEN1 | |
| SCHEMBL16720590 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1MYCPOLBMEN1 | |
| SCHEMBL2831953 | 0.82 | NR4A1 (1.00) | KDM4EALDH1A1MYCPOLBMEN1 | |
| SCHEMBL17172462 | 0.80 | MYC (0.72) | KDM4EALDH1A1MYCPOLBMEN1 | |
| SCHEMBL17172446 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1MYCPOLBMEN1 | |
| SCHEMBL17172469 | 0.79 | KEAP1 (0.64) | KDM4EALDH1A1MYCPOLBMEN1 | |
| SCHEMBL7823334 | 0.78 | ALDH1A1 (0.67) | KDM4EALDH1A1MYCPOLBMEN1 | |
| SCHEMBL15331958 | 0.78 | POLB (1.00) | KDM4EALDH1A1MYCPOLBMEN1 | |
| SCHEMBL4285406 | 0.78 | ALDH1A1 (0.63) | KDM4EALDH1A1MYCPOLBMEN1 | |
| SCHEMBL11176499 | 0.77 | POLB (0.63) | KDM4EALDH1A1MYCPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105240-A1 | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2009-04-23 | — | — | US | claimed |
| US-11129835-B2 | Methods and compositions for the inhibition of PIN1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-10980835-B2 | Arsenic trioxide for treatment of PIN1-associated disorders | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| US-20200093832-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2020-03-26 | — | — | US | disclosed |
| US-10413548-B2 | Methods and compositions for the inhibition of Pin1 | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| EP-2917203-B1 | METHOD FOR IDENTIFYING MYC INHIBITORS | DANA FARBER CANCER INST INC (US) | 2019-04-03 | — | — | EP | disclosed |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-07 | — | — | US | disclosed |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-07 | — | — | US | disclosed |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-26 | — | — | US | disclosed |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-26 | — | — | US | disclosed |
| US-7264932-B2 | Nuclease inhibitor cocktail | APPLERA CORPORATION (US) | 2007-09-04 | — | — | US | disclosed |
| US-7264932-B2 | Nuclease inhibitor cocktail | APPLERA CORPORATION (US) | 2007-09-04 | — | — | US | disclosed |
| US-20050014169-A1 | Nuclease inhibitor cocktail | AMBION, INC. | 2005-01-20 | — | — | US | disclosed |
| US-20040242868-A1 | 5-acylamino-1,1'-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2004-12-02 | — | — | US | disclosed |
| EP-1435934-A1 | 5'-ACYLAMINO-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032971-A1 | 5’-ACYLAMINO-1,1’-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
| EP-0062659-A4 | 3-(PYRROL-1-YL)PHENYLMETHYL ESTERS AND INTERMEDIATES. | FMC CORP (US) | 1983-01-14 | — | — | EP | disclosed |
| EP-0062659-A1 | 3-(PYRROL-1-YL)PHENYLMETHYL ESTERS AND INTERMEDIATES | FMC Corporation (US) | 1982-10-20 | — | — | EP | disclosed |
| US-4339457-A | OF CYCLOPROPANECARBOXYLIC ACIDS, INSECTICIDES, MITICIDES | FMC CORPORATION (US) | 1982-07-13 | — | — | US | disclosed |
| WO-1982001368-A1 | 3-(PYRROL-1-YL)PHENYLMETHYL ESTERS AND INTERMEDIATES | FMC CORP (US) | 1982-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242868-A1 | 5-acylamino-1,1'-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors | MAPK1, MAP3K1, MAPK7 | KDM4E 1140/4885ALDH1A1 531/4885MYC 1723/4885 |
| US-20090105240-A1 | Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same | MCL1, AS3MT, MYADM | KDM4E 3465/4885ALDH1A1 210/4885MYC 1076/4885 |
| US-10980835-B2 | Arsenic trioxide for treatment of PIN1-associated disorders | PIN1, AS3MT, PML | KDM4E 3689/4885ALDH1A1 2657/4885MYC 485/4885 |
| US-20200093832-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | KDM4E 3242/4885ALDH1A1 4586/4885MYC 257/4885 |
| US-20180153934-A1 | ARSENIC TRIOXIDE FOR TREATMENT OF PIN1-ASSOCIATED DISORDERS | PIN1, AS3MT, PML | KDM4E 3689/4885ALDH1A1 2657/4885MYC 485/4885 |
| US-20170304310-A1 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 | PIN1, FKBP1A, FKBP2 | KDM4E 3242/4885ALDH1A1 4586/4885MYC 257/4885 |
| US-11129835-B2 | Methods and compositions for the inhibition of PIN1 | PIN1, FKBP1A, FKBP2 | KDM4E 3242/4885ALDH1A1 4586/4885MYC 257/4885 |
| US-10413548-B2 | Methods and compositions for the inhibition of Pin1 | PIN1, FKBP1A, FKBP2 | KDM4E 3242/4885ALDH1A1 4586/4885MYC 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.