Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | TYMP | P19971 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116327 | 0.85 | PIM1 (0.42) | PIM1PIM2CYP2A6SLC40A1CYP1A2 | |
| SCHEMBL3336887 | 0.82 | NPC1 (0.50) | CYP2A6SLC40A1CYP1A2RAB9ANPC1 | |
| SCHEMBL13689579 | 0.81 | NCF1 (0.52) | PIM1ALDH1A1HSD17B10TSHRCYP3A4 | |
| SCHEMBL22970624 | 0.79 | SLC40A1 (0.46) | PIM1PIM2CYP2A6SLC40A1RAB9A | |
| SCHEMBL23406899 | 0.78 | ALDH1A1 (0.38) | PIM1PIM2SLC40A1CYP1A2ALDH1A1 | |
| SCHEMBL31184174 | 0.78 | ALDH1A1 (0.38) | PIM1PIM2SLC40A1CYP1A2ALDH1A1 | |
| SCHEMBL2116625 | 0.78 | METAP2 (0.52) | CYP2A6SLC40A1CYP1A2RAB9AALDH1A1 | |
| SCHEMBL2116650 | 0.77 | TDP1 (0.44) | PIM1PIM2RAB9ANPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2118473 | 0.76 | KCNQ3 (0.38) | CYP2A6CYP1A2ALDH1A1HSD17B10TSHR | |
| SCHEMBL22970626 | 0.75 | GSTP1 (0.47) | PIM1PIM2CYP2A6SLC40A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2012-04-19 | — | — | US | disclosed |
| CN-101959865-A | Quinolines as farnesyl pyrophosphate synthase inhibitor | NOVARTIS AG | 2011-01-26 | — | — | CN | disclosed |
| EP-2250152-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | Novartis AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009106586-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | FDPS, GGPS1, CTPS1 | PIM1 2265/4885PIM2 2437/4885CYP2A6 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.