Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 16/20 | 0.48 |
| ▸ | CDC7 | O00311 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170458 | 0.91 | MAPK1 (0.43) | MAPK1CDC7DAPK3ROCK2PRKD3 | |
| SCHEMBL21170450 | 0.84 | CDC7 (0.38) | MAPK1CDC7DAPK3ROCK2PRKD3 | |
| SCHEMBL21170309 | 0.84 | MAPK1 (0.38) | MAPK1CDC7DAPK3ROCK2PRKD3 | |
| SCHEMBL21170135 | 0.84 | MAPK1 (0.38) | MAPK1CDK2CDK9 | |
| SCHEMBL21170453 | 0.83 | NTRK1 (0.44) | MAPK1CLK2DYRK1ANTRK1GSK3B | |
| SCHEMBL12287892 | 0.83 | CDC7 (0.43) | MAPK1CDC7DAPK3ROCK2PRKD3 | |
| SCHEMBL21170338 | 0.81 | PSEN1 (0.39) | MAPK1CDK2CDK9 | |
| SCHEMBL21170049 | 0.81 | DYRK1A (0.38) | MAPK1CDC7DAPK3ROCK2PRKD3 | |
| SCHEMBL21170243 | 0.81 | MAPK1 (0.41) | MAPK1CDC7PIM1CDK9DYRK1A | |
| SCHEMBL21170454 | 0.80 | CCNT1 (0.36) | MAPK1CDK2CDK9DYRK1ANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |