Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170135 | 0.86 | MAPK1 (0.38) | CCNT1CDK9CDK2PSEN1PSEN2 | |
| SCHEMBL21170338 | 0.84 | PSEN1 (0.39) | CCNT1CDK9CDK2PSEN1PSEN2 | |
| SCHEMBL2555379 | 0.83 | PSEN1 (0.34) | CCNT1CDK9CDK2NTRK1PSEN1 | |
| SCHEMBL21170049 | 0.83 | DYRK1A (0.38) | CDK9CDK2NTRK1PSEN1PSEN2 | |
| SCHEMBL21170243 | 0.83 | MAPK1 (0.41) | CCNT1CDK9NTRK1PSEN1PSEN2 | |
| SCHEMBL21170453 | 0.82 | NTRK1 (0.44) | NTRK1MAPK1DYRK1A | |
| SCHEMBL21170458 | 0.81 | MAPK1 (0.43) | CDK9CDK2NTRK1MAPK1RAB9A | |
| SCHEMBL21170346 | 0.80 | MAPK1 (0.48) | CDK9CDK2NTRK1MAPK1DYRK1A | |
| SCHEMBL21170450 | 0.80 | CDC7 (0.38) | CCNT1CDK9CDK2PSEN1PSEN2 | |
| SCHEMBL21170342 | 0.78 | MAP2K4 (0.39) | CDK2NTRK1MAPK1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |