Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.37 |
| ▸ | CDK2 | P24941 | 5/20 | 0.37 |
| ▸ | CLK2 | P49760 | 5/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.37 |
| ▸ | PLK4 | O00444 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170458 | 0.86 | MAPK1 (0.43) | CDC7DAPK3CDK2CLK2CDK5 | |
| SCHEMBL21170346 | 0.84 | MAPK1 (0.48) | CDC7DAPK3CDK2CLK2CDK5 | |
| SCHEMBL12287849 | 0.82 | CDC7 (0.38) | CDC7MAP2K4DAPK3CDK2CLK2 | |
| SCHEMBL21170243 | 0.82 | MAPK1 (0.41) | CDC7DYRK1ACDK9PIM1MAPK1 | |
| SCHEMBL21170135 | 0.82 | MAPK1 (0.38) | CDK2CDK9MAPK1CCNT1PSEN1 | |
| SCHEMBL21170453 | 0.81 | NTRK1 (0.44) | CLK2DYRK1AMAPK1GSK3BLRRK2 | |
| SCHEMBL21170338 | 0.81 | PSEN1 (0.39) | CDK2CDK9MAPK1CCNT1PSEN1 | |
| SCHEMBL21170049 | 0.80 | DYRK1A (0.38) | CDC7DAPK3CDK2CLK2CDK5 | |
| SCHEMBL21170454 | 0.80 | CCNT1 (0.36) | CDK2DYRK1AMAPK12CDK9MAPK1 | |
| SCHEMBL21170217 | 0.79 | PSEN1 (0.36) | DYRK1ACDK9CCNT1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |