Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 14/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | WNT1 | P04628 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170049 | 0.92 | DYRK1A (0.38) | NTRK1DYRK1AGSK3BWNT1MAPK1 | |
| SCHEMBL21170458 | 0.85 | MAPK1 (0.43) | NTRK1DYRK1AGSK3BMAPK1CLK2 | |
| SCHEMBL21170135 | 0.84 | MAPK1 (0.38) | MAPK1 | |
| SCHEMBL21170338 | 0.84 | PSEN1 (0.39) | MAPK1 | |
| SCHEMBL21170346 | 0.83 | MAPK1 (0.48) | NTRK1DYRK1AGSK3BMAPK1CLK2 | |
| SCHEMBL21170243 | 0.83 | MAPK1 (0.41) | NTRK1DYRK1AMAPK1 | |
| SCHEMBL21170454 | 0.82 | CCNT1 (0.36) | NTRK1DYRK1AMAPK1 | |
| SCHEMBL12287338 | 0.82 | NTRK1 (0.44) | NTRK1DYRK1AGSK3BWNT1MAPK1 | |
| SCHEMBL21170450 | 0.81 | CDC7 (0.38) | DYRK1AGSK3BMAPK1CLK2LRRK2 | |
| SCHEMBL21170342 | 0.80 | MAP2K4 (0.39) | NTRK1DYRK1AGSK3BMAPK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |