Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 9/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170210 | 0.89 | NPC1 (0.36) | IL1BTNFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21170125 | 0.86 | IL1B (0.35) | IL1BTNFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21170329 | 0.82 | IL1B (0.34) | IL1BTNFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12287812 | 0.82 | HPGDS (0.40) | NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL21170229 | 0.81 | IL1B (0.37) | IL1BNPC1RAB9ASMN1; SMN2USP2 | |
| SCHEMBL21170422 | 0.81 | IL1B (0.35) | IL1BTNFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12286720 | 0.79 | NPC1 (0.40) | IL1BNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21170233 | 0.78 | IL1B (0.37) | IL1BTNFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21170105 | 0.78 | IL1B (0.36) | IL1BTNFNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21170275 | 0.73 | IL1B (0.34) | IL1BTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |